Name KUNG-YEE LIANG

Title Professor
Office National Health Research Institutes
Tel 886-2-2652-4100
Fax 886-2-8792-4080
E-mail kyliang@nhri.org.tw
Course Info Generalized Linear Models

EDUCATION AND TRAINING

1982    

Ph.D., Biomathematics - Biostatistics

University of Washington

Seattle, Washington

1979

M.S., Statistics

University of South Carolina

Columbia, South Carolina

1973

B.A., Mathematics

National Tsing Hua University

Hsin Chu, Taiwan, R.O.C.

PROFESSIONAL EXPERIENCES
     1991-Present

Professor, Department of Biostatistics

Bloomberg School of Public Health

The Johns Hopkins University

     1986-1990

Associate Professor, Department of Biostatistics

School of Hygiene and Public Health

The Johns Hopkins University

     1982-1986       

Assistant Professor, Department of Biostatistics

School of Hygiene and Public Health

The Johns Hopkins University

1996-2003        

Graduate Program Director

Department of Biostatistics

School of Hygiene and Public Health

The Johns Hopkins University

     1984-present 

Joint Appointment

Department of Epidemiology

School of Hygiene and Public Health

The Johns Hopkins University

     FaIl 1985

Academic Visitor, Imperial College

London, England

     August 1987 toFebruary 1988

Visiting Associate Professor

Institute of Biomedical Sciences

Academia Sinica

Taiwan, R.O.C.

    Summer 1989 

Visiting Associate Professor

Institute of Biomedical Sciences

Academia Sinica

Taiwan, R.O.C.

     Summer 1990

Visiting Associate Professor

Institutes of Biomedical Sciences and Statistical Sciences

Academia Sinica

Taiwan, R.O.C.

     Summer 1991 

Visiting Professor

Institute of Biomedical Sciences

Academia Sinica,

Taiwan, R.O.C.

     Summer 1992 

Visiting Professor

Institute of Public Health

National Taiwan University

Taiwan, R.O.C.

     1993-1994 

Visiting Professor

Institute of Public Health

National Taiwan University

Taiwan, R.O.C

     Summer 1995 

Visiting Professor

Institute of Epidemiology

National Taiwan University

Taiwan, R.O.C.

     1993-1996

Member of Regional Committee, Eastern North American Region of Biometrics Society.

     1993-1996

Member of Board of Directors, International Chinese Statistical Association.

     1993-2003

Associate Director and Director (from 1997), Psychiatric Biostatistics Training Program, Department of Biostatistics, Johns Hopkins University.

     1994- 1997

Member and Chair (from 1997) of Epidemiology and Genetic Review Committee, National Institute of Mental Health.

     Spring 1996

Co-Chair, Biostatistics Planning Committee, National Health Research Institutes, Taiwan, R.O.C.

     June 1996 

Program Chair, The Sixth Applied Statistics Symposium of International Chinese Statistical Association, Baltimore, Maryland.

     1996-Present

Member and Chair (from 2002) of the Advisory Committee for the Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taiwan, R.O.C.

     1997-Present

Member and Chair (from 2003) of the Public Health Review Committee, National Health Research Institutes, Taiwan, R.O.C.

     1998-Present

Member of the Advisory Committee for the National Medical Genetic Program, National Science Council, Taiwan, R.O.C.

     1998-Present

Member of Scientific Council, National Health Research Institutes, Taiwan,R.O.C.

     March 1998

Member of External Review Committee for the Graduate Institute of Health Care Organization Administration, National Taiwan University.

     April 1998

Member of Site Visit Team for the Biostatistics Branch, National Cancer Institute.

     March 1999 

Member of External Review Committee for the Graduate Institutes of Epidemiology (Chair), Occupational Medicine and Industrial Hygiene, and College of Public Health, National Taiwan University.

     December 1999

Member of External Review Committee for the Graduate Institute of Statistics, National Tsing Hua University, Taiwan, R.O.C.

     2000-Present

Member of the Advisory Committee for the Division of Health Policy, National Health Research Institutes, Taiwan, R.O.C.

     April 2002

Member of Site Visit Team for the Biostatistics Branch, National Cancer Institute.

PROFESSIONAL ACTIVITIES
     Spring 1986

Organizer for the invited session ¨Statistical Methodology for Cancer Epidemiology〃 of 1986 Biometrics Society spring meeting (Eastern American Region).

     Summer 1986

Organizer for General Methodology Lecture I:

        ¨Analysis of Categorical Data〃 of 1986 Joint Statistical Meeting.

     Fall 1987   

Organizer and speaker for the workshop on ¨Statistical Methods for

Case-Control Studies,〃 held in the Institute of Biomedical Sciences, Academia Sinica, Taiwan, R.O.C.

Summer 1988       

Co-organizer for the invited session ¨Statistical Methods in AIDS Research〃 of 1988 Joint Statistical Meeting.

     Summer 1989

Invited lecturer for the workshop on ¨Design and Statistical Analysis of Cohort Studies,〃 held in the Institute of Biomedical Sciences, Academia Sinica, Taiwan, R.O.C.

     April 1990

Organizer for the invited session ¨Estimating Functions: Overview and Some Biostatistics Applications〃 of 1990 Biometrics Society Spring Meeting (Eastern North American Region).

     April 1990

Invited lecturer for the short course on ¨Regression Analysis for

Dependent Responses〃 of 1990 Biometrics Society Spring Meeting

(Eastern North American Region).

     Summer 1990

Invited lecturer for the workshop on ¨Design and Statistical Analysis of Intervention Studies,〃 held in the Institute of Biomedical Sciences, Academia Sinica, Taiwan, R.O.C.

     Summer 1990

Invited lecturer for the short course on ¨Regression Analysis for Dependent Responses,〃 held in the Institute of Statistical Sciences, Academia Sinica, Taiwan, R.O.C.

     Summer 1990

Discussant for the invited session ¨Recent Development on Conditional and Marginal Inference〃 of 1990 Joint Statistical Meeting.

     Fall 1990

Invited lecturer for the short course on ¨Statistical Analysis for

Longitudinal Data,〃 held at Merck, Sharp and Dome Research Laboratories.

     December 1990

Invited speaker for the workshop on ¨Estimating Functions:   Overview and Applications〃 held at LaTrobe University, Bundoora Victoria, Australia.

     March 1991

Discussant for the invited session ¨Methods for the Analysis of Repeated categorical Measurement Data〃 of 1991 Biometrics Society spring meeting.

     June 1991

Invited speaker for the symposium on ¨Longitudinal Data Analysis〃

sponsored by the Biopharmaceutical Section of the American Association.

     June 1991

Speaker for the invited session ¨Correlated Binary Data〃 of 1991 Canada Statistical Society Meeting.

     June 1991

Invited lecturer for the short course on ¨Regression Analysis for Dependent Responses〃 of 1991 Biometrics Society spring meeting (Western North American Region).

     September 1991

Invited lecturer for the short course on ¨Regression Analysis for Dependent Responses〃 sponsored by Laboratory for Research in Statistics and Probability, Ottawa, Canada.

     February 1992

Invited lecturer for the workshop on ¨Statistical Analyses of Correlated Data in Epidemiological Studies,〃 held in the Institute of Biomedical Sciences, Academia Sinica, Taiwan, R.O.C.

     September 1992

Invited lecturer for the short course on ¨Longitudinal Data Analysis〃 of 1992 Royal Statistical Society Annual Meeting, Sheffield, England.

     November 1992

Invited lecturer for the short course on ¨Regression analysis for Dependent Responses,〃 held at Janssen Research Foundation.

     January 1993

Invited lecturer for the short course on ¨Analysis of Longitudinal Data,〃 held at the Center for Disease Control, Atlanta.

     April 1993

Invited lecturer for the short course on ¨Analysis of Longitudinal Data〃 held at Burroughs Wellcome Company.

     June 1993

Invited lecturer for the workshop on ¨Regression Analysis for Dependent Responses〃 of 1993 Canadian Statistical Society Annual Meeting, Wolfville, Canada.

     June 1993

Invited lecturer for the workshop on ¨Repeated Measurements and Correlated Data〃 sponsored by German Region of Biometrics Society, Munich, Germany.

     July 1993

Special invited speaker for the 1993 European Meeting of the Psychometric Society, Barcelona, Spain.

     August 1993

Organizer for the invited session ¨Analysis of Correlated Data〃 of 1993 Joint Statistical Meeting.

     November 1993

Invited lecturer for the short course on ¨Regression Analysis for

Correlated Data,〃 sponsored by the Italian Region of the International Biometric Society, Montecatini, Italy.

     June 1995

Invited lecturer for the short course on ¨Genetic Epidemiology,〃 jointly sponsored by Italian National Institutes of Health and the Italian Region of  International Biometric Society, Rome, Italy.

     July 1995

Invited lecturer for the workshop on ¨Generalized Linear Models and Estimating Functions,〃 sponsored by the National Science Council, Taiwan, R.O.C.

     August 1995

Invited lecturer for the short course on ¨Analysis of Longitudinal Data,〃 sponsored by the American Statistical Association, Orlando.

     March 1996

Organizer for the invited session ¨Causal Inference: Econometric and Biostatistics Perspectives〃 of the 1996 Biometrics Society spring meetings.

     April 1996

Invited lecturer for the short course on ¨Analysis of Longitudinal Data,〃 sponsored by the Food and Drug Administration.

     February 1997

Invited lecturer for the short course on ¨Advanced Methods for Longitudinal Data Analysis,〃 held at Janssen Research Foundation.

     June 1997

Invited lecturer for the short course on ¨Longitudinal Data Analysis Using Generalized Linear Models,〃 the 7th Applied Statistics Symposium, International Chinese Statistical Association.

     February 1998

Invited lecturer for the short course on ¨Dose-response Modeling in the Evaluation of New Drugs,〃 held at Janssen Research Foundation.

     March 1998

Invited lecturer for the short course on ¨Updates on Statistical Methods for Longitudinal Studies〃 at the 1998 Biometrics Society spring meeting (Eastern North American Region).

     July 1998

Invited lecturer for the workshop on ¨Design and Analysis for Genetic Epidemiology,〃 held at the Institute of Biomedical Science, Academia Sinica, Taiwan, R.O.C.

     February 1999

Invited lecturer for the short course on ¨Some Modern Developments of Survival Data Analysis,〃 held at Janssen Research Foundation.

     June 1999

Invited lecturer for the short course on ¨Longitudinal Data Analysis Using Generalized Linear Models,〃 the 9th Applied Statistics Symposium, International Chinese Statistical Association.

     July 1999

Invited lecturer for the workshop on ¨Generalized Linear Models, Estimating Functions and Multivariate Extensions.〃 Sponsored by the Institute of Statistical Science, Academia Sinica, Taiwan, R.O.C.

     October 1999

Invited lecturer for the short course on ¨Longitudinal Data Analysis Using Generalized Linear Models,〃 held at Novartin Pharmaceuticals, Basal, Switzerland.

     June 2000

Invited lecturer for the short course on ¨Designs and Analyses for Genetic Epidemiology,〃 the 10th Applied Statistics Symposium, International Chinese Statistical Association.

     July 2000

Invited lecturer for the short course on ¨Analysis of Data from Longitudinal Studies:   Current Topics,〃 International Biometrics Conference 2000.

     July 2000

Invited lecturer for the short course on ¨Longitudinal Data Analysis,〃

Summer Institute of Biostatistical Science, National Health Research

Institutes, Taiwan, R.O.C.

     December 2000

Invited lecturer for the Preventive Medicine/Public Health Grand Rounds, Johns Hopkins School of Public Health.

     July 2001

Invited lecturer for the short course on ¨The Analysis of Repeated Multi­Idem Responses in Clinical Trials,〃 held at Janssen Research Foundation.

     July 2002

Invited lecturer for the short course on ¨Genetic Epidemiology: Design and Analysis,〃 Summer Institute of Biostatistical Science, National Health Research Institutes, Taiwan, R.O.C.

     January 2003 Invited lecturer for the short course on ¨Genetic Epidemiology,〃 held at University of Nijmegen, Nijmegen, The Netherlands.

PROFESSIONAL AFFILIATIONS

     International Biometrics Society (ENAR)

     Royal Statistical Society

     International Chinese Statistical Association

     International Genetic Epidemiology Society

     Society of Chinese Bioscientists in America

EDITORIAL ACTIVITIES
     1986-1991

Associate Editor, Journal of American Statistical Association -Applications

     1988-1993 Associate Editor, Statistica Sinica
     1994-2000    Associate Editor, Biometrics

HONORS AND AWARDS
     1987

American Statistical Associationˇs Snedecor Award (with Scott Zeger) for best publication in Biometry for 1986.

     1990

American Public Health Associationˇs Spiegelman Award for outstanding accomplishments in the field of health statistics.

     1991

Member of Alpha Chapter, Delta Omega Society.

     1995

Elected Fellow, American Statistical Association.

     1997

Advising, Mentoring and Teaching Recognition Award, Johns Hopkins School of Hygiene and Public Health Student Assembly.

     2000

2000 Bernard G. Greenberg Distinguished Lecturer, Department of Biostatistics, University of North Carolina.

     2002

Elected Academician, Academia Sinica, Taiwan, R.O.C.

PUBLICATIONS
    Journal Articles

1.  Liang KY, Padgett WJ (1981). Nonparametric empirical Bayes estimation of reliability. Metron 30:143-152.

2.  Breslow NE, Liang KY (1982). The variance of the Mantel-Haenszel estimator. Biometrics 38:943-952.

3.  Judzewitsch RG, Jaspar JB, Polonsky KS, Weinberg CR, Halter JB, Halar E, Pfeifer MA, Vukadinovic C, Bernstein L, Schneider M, Liang KY, Grabbeny KH, Rubeinstein AH, Porte D (1983). Aldose reductase inhibition improves nerve conduction velocity in diabetic patients. New England Journal of Medicine 308:118-125.

4 Liang KY (1983). On information and ancillarity in the presence of a nuisance parameter. Biornetrika 70:607-6 12.

5.  Liang KY (1984). The asymptotic efficiency of the conditional likelihood methods. Biometrika 71:305-3 13.

6Zeger 5, Liang KY, Self SG (1985). The analysis of binary longitudinal data with time independent covariates. Biometrika 72:3 1-38.

7.  Liang KY, Self SG (1985). Tests for homogeneity of odds ratios when the data are sparse. Biometrika 72:353-358.

8.  Liang KY (1985). Odds ratio inference with dependent data. Biometrika 72:678-682.

9.  Beaty TH, Self SG, Liang KY, Connolly MA, Chase GA, Kwiterovich P0 (1985). Use of robust variance components models to analyze triglyceride data in families. Annals of Human Genetics 49:315-328.

10Liang KY (1985). Book review on ¨Introduction to Statistical Methods〃 by J.S. Rustagi. Short Book Review 5:38.

11Liang KY, Zeger 5 (1986). Longitudinal data analysis using generalized linear models. Biometrika 73:13-22.

12Zeger SL, Liang KY (1986). Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42:12 1-130.

13.  Liang KY, Beaty TH, Cohen BH (1986). Application of odds ratio regression models for assessing familial aggregation from case-control studies. American Journal of Epidemiology 124:678-683.

14.  Brookmeyer R, Liang KY, Linet M (1986). Matched case-control designs and overmatched analysis. American Journal of Epidemio]pgy 124:693-70

15.  LaCroix AZ, Mead LA, Liang KY, Pearson TA (1986). Coffee consumption and incidence of coronary heart disease. New England Journal of Medicine 315:977-982.

16.  Self SG, Liang KY (1987). Large sample properties of the maximum likelihood estimator and the likelihood ratio test on the boundary of the parameter space. Journal of the American Statistical Association 82:605-611.

17.  Liang KY, Stewart WF (1987). Polychotomous logistic regression methods for matched case-control studies with multiple case and control groups. American Journal of Epidemiology 125:720-730.

18 Liang KY (1987). A locally most powerful test for homogeneity with many strata. Biometrika 74:259-264.

19 Liang KY (1987). Extended Mantel-Haenszel estimating procedure for multivariate logistic regression models. Biometrics 43:289-299.

20 Liang KY (1987). Estimating functions and approximate conditional likelihood. Biometrika 74:695-702.

21 Beaty TH, Liang KY (1987). Robust variance components analysis in families ascertained through probands I: conditioning on probandˇs phenotype. Genetic Epidemiology 4:203-210.

22 Beaty TH, Liang KY, Seerey S, Cohen BH (1987). Robust variance components analysis in families ascertained through probands II: analysis of spirometric measures. Genetic Epidemiology 4:211-221.

23 Khoury MJ, Beaty TH, Liang KY (1988). Can familial aggregation of disease be explained by familial aggregation of environmental risk factors? American Journal Epidemiology 127:674-683.

24 Liang KY, Stewart WF (1988). The Authors reply: Polychotomous logistic regression methods for matched case-control studies with multiple case and control groups. American Journal of Epidemiology 128:448-449.

25 Connolly M, Liang KY (1988). Conditional logistic regression models for correlated binary data. Biometrika 75:501-506.

26 Zeger 5, Liang KY, Albert P (1988). Models for longitudinal data: a generalized estimating equation approach. Biometrics 44:1049-1060.

27 Liang KY, Zeger SL (1988). On the use of concordant pairs in matched case-control studies. Biometrics 44:1145-1156.

28 Maestri NE, Beaty TH, Liang KY, Boughman JA, Ferencz C (1988). Assessing familial aggregation of congenital cardiovascular malformations in case-control studies. Genetic Epidemiology 5:343-354.

29.  Paul SR, Liang KY, Self SG (1989). On testing departure from the binomial and multinominal assumptions. Biometrics 45:231-236.

30 Liang KY, Zeger SL (1989). A class of logistic regression models for multivariate binary time series. Journal of the American Statistical Association 84:447-451.

31 Chen CJ, Liang KY, Chang YS, Wang YF, Hsieh T, Hsu MM, Chen CY, Liu MY (1989). Multiple risk factors of Nasopharyngeal carcinoma: Epstein-Barr virus, Malarial infection, cigarette smoking and familial tendency. Anti Cancer Research 10:547-554.

32 Yang P, Beaty TH, Khoury MJ, Liang KY, Connolly MA (1989). Predicting intrauterine growth retardation in sibships considering maternal and infant covariates. Genetic Epidemiology 6:525-535.

33 Menkes MS, Matthews KA, Krantz DS, Lundberg U, Mead LA, Qaqish B, Liang KY, Thomas CB, Pearson TA (1989). Cardiovascular reactivity to the cold pressor test as a predictor of hypertension. Hypertension 14:524-530.

34 Wang CN, Whelton PK, Hamper UM, Connolly MA, Kadir S, White RI, Sanders R, Liang KY, Bias W (1989). Etiological factors in renovascular fibromuscular dysplasia: a case-control study. Hypertension 14:472-479.

35 Pearson TA, LaCroix AZ, Mead LA, Liang KY (1990). The prediction of midlife coronary artery disease and hypertension in young adulthood: The Johns Hopkins Multiple risk equations. American Journal of Preventive Medicine Supplement 6:23-28.

36 Liang KY (1990). Discussion on ¨Combining moment estimates of a parameter common through strata.〃 Journal of Statistical Planning and Inference 25:195-196.

37 Liang KY, Waclawiw MA (1990). Extension of the Stein estimating procedure through the use of estimating functions. Journal of American Statistical Association 85:435-440.

38 Liang KY, Self SG, Liu, X (1990). Coxˇs proportional hazards model with change point: An epidemiologic application. Biometrics 46:783-793.

39 Self SG, Longton G, Kopecky KJ, Liang KY (1991). On estimating HLAldisease association with application to a study of aplastic anemia. Biometrics 47:53-62

40 Zeger SL, Liang KY (1991). Feedback models for discrete and continuous series. Statistica Sinica 1:51-64.

41 Zeger SL, Liang KY (1991). Discussion on ¨Compliance as an explanatory variable in clinical trials.〃 Journal of American Statistical Association 86:18-19.

42 Chen CJ, Liang KY, Chang AS, Chang YL, Lu SN, Lin TM, Chang WY, Sheen MC, Liaw YF (1991). Independent effects of hepatitis B. virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma. Hepatology 13:398-406.

43 Liu X, Liang KY (1991). Adjustment for nondifferential misclassification error in the generalized linear model. Statistics in Medicine 10:119-1211.

44 Beaty TH, Khoury MJ, Yang P, Harris EL, Liang KY (1991). Using log-linear models to test for associations among congenital malformations. American Journal of Medical Genetics 39:299-306.

45 Liang KY, Beaty TH (1991). Measuring familial aggregation using odds ratio regression models. Genetic Epidemiology 8:361-370.

46 Liang KY (1991). Estimating effects of probandsˇ characteristics on familial risk: I. Adjustment for censoring and correlated ages at onset. Genetic Epidemiology 8:329-338.

47 Pulver AE, Liang KY (1991). Estimating effects of probandsˇ characteristics on familial risk: II. The association between ages at onset and familial risk in the Maryland schizophrenia sample. Genetic Epidemiology 8:339-350.

48 Starfield B, Shapiro S, Weiss J, Liang KY, Ra K, Paige D, Wang X (1991). Race, family income and low birthweight. American Journal of Epidemiology 134:1167-1174.

49 Roubenoff R, KIag MJ, Mead LA, Liang KY, Seidler AJ, Hochberg MC (1991). Incidence and risk factors for gout in white men. Journal of American Medical Association 266:3 004-3007.

50 Liang KY, Zeger SL, Qaqish B (1992). Multivariate regression analyses for categorical data (with discussion). Journal of Royal Statistical Society series B, 54:3-40.

51 Pulver AE, Liang KY, Brown CH, Wolyniec PS, McGrath J, Adler J, Tam D. Carpenter WT, Childs B (1992). Risk factors in schizophrenic: season of birth, gender and familial risk. British Journal of Psychiatry 160:65-71.

52 Pulver AE, Liang KY, Wolyniec PS, McGrath J, Melton BA, Childs B (1992). Season of birth of siblings of schizophrenic patients. British Journal of Psychiatry 160:71-75.

53 Liu X, Liang KY (1992). Efficacy of repeated measures in regression model with measurement error. Biometrics 48:645-654.

54 Coresh J, Kiag MJ, Mead LA, Liang KY, Whelton PK (1992). Vascular reactivity in young adults and cardiovascular disease: A prospective study.  Hypertension 19:218-223.

55 Liang KY, Tsou D (1992). Empirical Bayes and conditional inference with many nuisance parameters. Biornetrika 79:26 1-270.

56 Qaqish B, Liang KY (1992). Marginal models for correlated binary data with multiple classes and multiple levels of nesting. Biometrics 48:939-950.

57 Zeger SL, Liang KY (1992). An overview of methods for analysis of longitudinal data. Statistics in Medicine 11:1825-1839.

58 Liang KY, Self SG, Chang YC (1993). Modeling for marginal hazards in multivariate failure-time data. Journal of the Royal Statistical Society Series B, 55:441-453.

59 Waclawiw MA, Liang KY (1993). Estimation of random effects in the generalized linear models. Journal of American Statistical Association 88:171-178.

60 Beaty TH, Colyer CR, Chang YC, Liang KY, Graybeal J, Muhammad NK, Levin LS (1993). Familial aggregation of measures of periodontal health. Journal of Dental Research 72:544-551.

61 Liang KY, McCullagh P (1993). Case studies in binary dispersion. Biometrics 49:623-630.

62 Liang KY, Zeger SL (1993). Regression analysis for correlated data. Annual Review of Public Health 14:43-68.

63 Kiag MJ, Ford DE, Mead LA, He J, Whelton PK, Liang KY, Levine DM (1993). Serum cholesterol in young adulthood and premature cardiovascular disease. New England Journal of Medicine 328:313-318.

64 Waclawiw MA, Liang KY (1994). Empirical Bayes estimation and inference for the random effects model with binary response. Statistics in Medicine 13:541-551.

65 Katz J, Zeger 5, Liang KY (1994). Choosing appropriate statistical methods to account for similarities between fellow eyes. Investigative Ophthalmology and Visual Sciences 35:2461-2465.

66 Chang YC, Liang KY (1994). Estimation in the exponential family in the presence of nuisance parameters: compromise between bias and precision. Statistica Sinica 4:169-185.

67.  Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonarakis 5, Housman D, Kazazian HH, Meyers D, Ott J, Lamacz M, Liang KY et al. (1994). Sequential strategy to identify a susceptibility gene for schizophrenia:: report of potential linkage on chromosome 22 q-12-q 13.1: part 1. American Journal of Medical Genetics (Neuropsychiatric Genetics) 54:36-43.

68 Pulver AE, Karayiorgou M, Lasseter VK, Wolyniec P, Kasch L, Antonarakis 5, Housman D, Kazazian HH, Meyers D, Nestadt G, Ott J, Liang KY et al. (1994). Follow-up of a report of a potential linkage for schizophrenia: on chromosome 22 q 12-q 13.1: Part 2, American Journal of Medical Genetics (Neuropsychiatric Genetics) 54:44-50.

69 Melton B, Liang KY, Pulver AE (1994). An extended latent class approach to the study of familial/sporadic forms of a disease: its applications to the study of the heterogeneity of schizophrenia. Genetic Epidemiology 11:311-327.

70 Liang KY, Hanfelt J (1994). On the use of the quasi-likelihood method in teratological experiments. Biometrics 50:872-880.

71 Nestadt G, Hanfelt J, Liang KY, Lamacz M, Wolyniec P, Pulver AE (1994). An evaluation of the structure of schizophrenia spectrum personality disorders. Journal of Personality Disorder 8:288-298.

72 Hwang SJ, Beaty TH, Liang KY, Coresh J, Khouny MJ (1994). Minimum sample size estimation to detect gene-environment interaction in case-control designs. American Journal of Epidemiology 140:1029-1037.

73 Kiag MJ, Mead LA, La Croix AZ, Wang NY, Coresh J, Liang KY, Pearson TA, Levine DM (1994). Coffee intake and coronary heart disease. Annals of Epidemiology 4:425-433.

74 Eaton WW, Thara R, Federman B, Melton B, Liang KY (1995). Structure and course of positive and negative symptoms in schizophrenia. Archives of General Psychiatry 52:127-134.

75 Hanfelt JJ, Liang KY (1995). Approximate likelihood ratio for general estimating functions. Biometrika 82:461-477.

76 Liang KY, Zeger SL (1995). Inference based on estimating functions in the presence of nuisance parameters (with discussion). Statistical Science 10:158-172.

77 Liang KY, Self SG, Bandeen-Roche KJ, Zeger SL (1995). Some recent developments for regression analysis of multivariate failure time data. Lifetime Data Analysis 1:403-415.

78 Knöbel HH, Chen CC, Liang KY (1995). Sudden unexpected infant deaths in relation to weather and optimetrically measured air pollution in Taiwan. Pediatrics 96:1106-1110.

79 Liang KY, Self SG (1996). On the asymptotic behavior of the pseudo-likelihood ratio test statistic. Journal of the Royal Statistical Society Series B 59:785-796.

80 Wang N, Carroll RJ, Liang KY (1996). Quasilikelihood and variance functions in normal measurement error models with replicates. Biometrics 52:401-411.

81 King, TM, Beaty TH, Liang, KY (1996). Comparison of methods of survival analysis of dependent data. Genetic Epidemiology 13:139-158.

82 Bandeen-Roche KJ, Liang KY (1996). Modeling failure-time association in data with multiple levels of clustering. Biometrika 83:29-39.

83 Liang KY, Pulver A (1996). Analysis of case-control/family sampling design in psychiatric research. Genetic Epidemiology 13:253-270.

84 Liang KY, Rohde CA, Hanfelt J (1996). Instrumental variable estimation and estimation functions. Statistica Applicata 8:43-58.

85 Liang KY, Rathouz P, Beaty TH (1996). Determining linkage and mode of inheritance: mod scores and other methods. Genetic Epidemiology 13:575-593.

86 Hanfelt JJ, Liang KY (1997). Approximate likelihood methods for generalized linear errors-in-variables models. Journal of the Royal Statistical Society, Series B 59:627-637.

87 Beaty TH, Skjaerven R, Breazeale DR, Liang KY (1997). Analyzing sibship correlations in birth weight using large sibships from Norway. Genetic Epidemiology 14:423-433.

88 Liu G, Liang KY (1997). Sample size calculations for studies with correlated observations. Biometrics 53:937-947.

89 Maestri NE, Beaty TH, Hetmanski J, McIntosh I, Smith, EA, Wyszynski DF, Liang KY, Duffy DL, Vanderkolk C (1997). Transmission disequilibrium tests with nonsyndromic oral clefts: candidate genes and environmental exposures. American Journal of Medical Genetics 73:337-344.

90 Liang KY, Brown C (1997). Editorial: Some statistical issues in psychiatric epidemiology research. Epidemiologia e Psichiatria Sociale. 6:151-154.

91 Hanfelt JJ, Liang KY (1998). Statistical inference for odds ratio regression models with sparse dependent data. Biometrics 54:136-147.Reboussin BA, Liang KY (1998). An estimating equations approach for the LISCOMP model. Psychometrika 63:165-182.

92 Reboussin BA, Reboussin DM, Liang KY, Anthony JC (1998). A latent transition approach for modeling progression of health-risk behavior. Multivariate Behavioral Research 33:457-458.

93 Rosenblatt A, Margolis RL, Becher MW, Aylward E, Franz ML, Sherr M, Abbot M, Liang KY, Ross CA (1998). Does CAG repeat numbers predict rate of pathologic changes in Huntingtonˇs disease? Annals of Neurology 44:708-709.

94 Liang KY, Rathouz PJ (1999). Hypothesis testing under mixture models: application to genetic linkage analysis. Biometrics 55:65-74.

95 Lyketsos CG, Garrett E, Liang KY, Anthony JC (1999). Cannabis use and cognitive decline in persons under 65. American Journal of Epidemiology 149:794-800.

96 Brancati FL, Wang NY, Mead LA, Liang KY, Klag MJ (1999). Body weight in early adulthood and the risk of diabetes mellitus in middle age: the Johns Hopkins Precursors Study. Archives of Internal Medicine 159:957-963.

97 Zeger SL, Liang KY (1999). Discussion on ¨Estimation of the causal effect of a time-varying exposure on the marginal mean of a repeated binary outcome.〃 Journal of the American Statistical Association 94:707-707.

98 Reboussin BA, Liang KY, Reboussin DM (1999). Estimating equations for a latent transition model with multiple discrete indicators. Biometrics 55:839-845.

99 Rathouz P and Liang KY (1999). Reducing sensitivity to nuisance parameters in semiparametric models: a quasiscore method. Biometrika 86:857-869.

100 Myers AH, Baker SP, Li G, Smith G., Wiker 5, Liang KY, Johnson JV (1999). Back injury in municipal workers: a case-control study. American Journal of Public Health 89:1036-1041.

101.  Mathias RA, Bickel CA, Beaty TH, Petersen GM, Hetmanski JB, Liang KY, Barnes KC (2000). A study of contemporary levels and temporal trends in inbreeding in the Tangier Island, Virginia population using pedigree data and isonymy. American Journal of Physical Anthropology 112:29-38.

102 Liang KY, Huang CY, Beaty TH (2000). A unified multipoint method for qualitative and quantitative traits in sib pairs. American Journal of Human Genetics 66:1631-1641.

103Nestadat G, Samuels J, Bienvenu OJ, Grados M, Hoehn-Sanic R, Liang KY, LaBuda M, Riddle M, Walkings J (2000). A family study of obsessive compulsive disorder. Archives of General Psychiatry 57:358-363.

104 Liang KY and Zeger SL (2000). Longitudinal data analysis of continuous and discrete responses for pre-post designs. Sankhya Series B 62:134-148.

105 Liang KY and Qin J (2000). Regression analysis under non-standard situations: a pairwise pseduo-likelihood approach. Journal of the Royal Statistical Society Series B 62:773-786.

106 Bienvenu OJ, Nestadt G, Samuels, Liang KY, Hoen-Sanic R, Cullen B, Grados M, Riddle M (2000). The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biological Psychiatry 48:287-293.

107 Saniuels J, Nestadt G, Bienvenu OJ, Costa P1, Riddle M, Liang KY, Hoehn-Sanic R, Grados M, Cullen B (2000). Personality disorders and normal personality dimensions in obsessive-compulsive disorder: results from the Johns Hopkins OCD Family Study. British Journal of Psychiatry 177:456-462.

108 Nestadt G, Lan T, Samuels JR, Riddle M, Bienvenu OJ, Liang KY, Hoehn-Sanic R, Cullen B, Grados M, Beaty TH, Shugart YY (2000). Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder (OCD) and heterogeneity by gene. American Journal of Human Genetics 67:1611-1616.

109 Pulver AE, Mulle J, Nestadt G, Swartz K, Blouin JL, Dombroski B, Liang KY, Houseman DE, Kazazian HH, Antonarakis SE, Lasseter VK, Wolyniec PS, Thomquist M, McGrath J (2000). Genetic heterogeneity in schizophrenia: estimation of genome scan data using co-segregating related phenotypes. Molecular Psychiatry 5:650-653.

110 Liang KY, Beaty TH (2000). Statistical designs for familial aggregation. Statistical Methods in Medical Research 9:543-562.

111 Liang KY, Chiu YF, Beaty TH (2001). A robust identity by descent procedure using affected sib pairs: a multipoint approach for complex diseases. Human Heredity 51:64-78.

112 Liang KY, Hsu FC, Beaty TH, Barnes KC (2001). Multipoint linkage disequilibrium mapping approach based on the case-parent trio design.  American Journal of Human Genetics 68:937-950.

113 Cullen BA, Samuels JF, Bienvenu OJ, Grados M, Hoehn-Sanic R, Hahn J, Liang KY, Wellen D, Dees M, Riddle MA, Nestadt G (2001). The relationship of pathologic skin picking of obsessive-compulsive disorder. Journal of Nervous and Mental Disorder 189:193-195.

114 Nestadt G, Samuels J, Riddle M, Liang KY, Bienvenu OJ, Hoehn-Sanic R, Grados M, Cullen B (2001). The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study. Psychological Medicine 31:481-487.

115 Bienvenu OJ, Brown C, Samuels JF, Liang KY, Costa PY, Eaton WW, Nestadt G (2001). Normal personality traits and comorbidity among phobic, panic and major depressive disorders. Psychiatry Research 102:73-85.

116.  Beaty TH, Wang H, Hetmanski JB, Fan YT, Zeiger JS, Liang KY et al. (2001). A case-control study of nonsydromic oral clefts in Maryland. Annals of Epidemiology 11:434-442.

117.  Rosenblatt A, Brinkman RR, Liang KY, Almqvist EW, Margolis RL, Huang CY, Sherr M, Frnaz ML, Abbort MH, Hayden MR, Ross CA (2001). Familial influence on age of onset among siblings with Huntingtonˇs disease. American Journal of Medical Genetics 105:399-403.

118 Liang KY, Chiu YF, Beaty TH, Wjst M (2001). A multipoint analysis using affected sibpairs: incorporating linkage evidence from unlinked regions. Genetic Epidemiology 21:105-122.

119 Rathouz PJ, Liang KY (2001). Locally ancillary quasiscore models for errors-in-covariates. Journal of the American Statistical Association 96:1004-1013.

120 Crum RM, Brown C, Liang KY, Eaton W (2001). The association of depression and problem drinking: analyses from the Baltimore ECA follow-up study. Addictive Behaviors 26:765-773.

121 Chiu YF, Addington A, Beaty TH, Klein AP, Liang KY (2001). Multipoint linkage analysis under heterogeneity: incorporation of parametric and nonparametric approaches. Genetic Epidemiology 21(Suppl 1):55-60.

122 Grados M, Riddle M, Samuels J, Liang KY, Hoehn-Sanic R, Bienvenu OJ, Walkup JT, Song DH, Nestadt G (2001). The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD Family Study. Biological Psychiatry 50:559-565.

123 Breslau N, Chilcoat HD, Susser ES, Matte T, Liang KY, Peterson EL (2001). Stability and change in childrenˇs IQ score: a comparison of two socio-economically disparate populations. American Journal of Epidemiology 154:711-717.

124 Scharfstein DO, Liang KY, Eaton WW, Chen LS (2001). The quadratic cumulative odds regression model for scored ordinal outcomes: application to alcohol dependence. Biostatistics 2:473-483.

125 Beaty TH, Helmanski JB, Zeiger JS, Fan YT, Liang KY, VanderKolk CA, McIntosh I (2002). Testing candidate genes for oral clefts using the case-parent trio design. Genetic Epidemiology 22:1-11.

126 Kiag MJ, Wang NY, Mead LA, Brancati FL, Cooper L, Liang KY, Ford DE (2002). Coffee intake and risk of hypertension: The Johns Hopkins Precursor Study. Archives of Internal Medicine 162:657-662.

127 Hsu FC, Liang KY, Beaty TH, Barnes KC (2002). A unified sampling approach for multipoint linkage disequilibrium mapping of quantitative and qualitative traits. Genetic Epidemiology 22:298-312.

128 Samuels J, Bienvenu OJ, Riddle MA, Cullen BKM, Grados MA, Liang KY, Hoehn-Sanic R, Nestadt G (2002). Hoarding in obsessive-compulsive disorder. Behavioral Research and Therapy 40:517-528.

129 Chiu YF, Liang KY, Beaty TH (2002). Multipoint linkage detection in the presence of heterogeneity. Biostatistics 3:195-211.

130 Bandeen-Roche K, Liang KY (2002). Modelling multivariate failure time associations in the presence of competing risk. Biometrika 89:299-314.

131Levinson DF, Holmans PA, Laurent C, Riley B, Pulver AE, Gejman PV, Schwab SG, Williams NM, Owen MJ, Wildenauer DG, Sanders AR, Nestadt G, Mowiy BJ, Wormley B, Bauche 5, Soubigou 5, Ribble R, Nertney DA, Liang KY, Martinolich L, Maier W, Norton N, Williams H, Albus M, Carpenter B, deMarchi N, Ewen-White KR, Walsh D, Jay M, Deleuze JF, OˇNeill FA, Papadimitrious G, Weilbaecher A, Lere B, OˇDonovan MC, Kikeos D, Silverman JM, Kendler KS, Mallet J, Crowe RR, Walters M. (2002). No major schizophrenia locus detected on chromosome lq in a large multicenter sample. Science 96:739-741.

132 Nestadt G, Samuels J, Riddle MA, Bienvenu OJ, Liang KY, Grados M, Culler B (2002). OCD: defining the phenotype. Journal of Clinical Psychiatry 63:5-7.

133 Houston TK, Mead LA, Ford DE, Brancati FL, Cooper-Patrick L, Levine DM, Liang KY, Kiag MJ (2002). Sports ability in young adulthood and incidence of cardiovascular diseases. American Journal of Medicine 112:689-695.

134Chiu YF, McGrath JA, Thornquist MH, Wolyniec PS, Nestadt G, Swartz K, Lasseter VK, Liang KY, Pulver AE (2002). Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provides evidence for an interaction between markers on chromosomes 8p and 14q. Molecular Psychiatry 7:658-665.

135 Glidden DV, Liang KY (2002). Ascertainment adjustment in complex diseases (with discussion). Genetic Epidemiology 23:201-220.

136 Fallin D, Chen W, Beaty TH, Liang KY (2002). Letter to the editor: power comparisons for genotypic versus allelic TDT methods with> 2 alleles. Genetic Epidemiology 23:458-461.

137 Glidden DV, Liang KY, Chiu YF, Pulver AE (2003). Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases. Genetic Epidemiology 24:107-117.

138 Nestadt G, Addington A, Samuels J, Liang KY, Bienvenu OJ, Riddle M, Grados M, Hoehn-Sarie R, Cullen B (2003). The identification of subgroups within the OCD phenotype. Biological Psychiatry 53:914-920.

139 Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang KY, Pulver AE (2003). Genome-wide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence for linkage on chromosome 10q22. To appear in American Journal of Human Genetics.

140 Hsu FC, Liang KY, Beaty TH and CSGA (2003). A multipoint linkage disequilibrium mapping approach: incorporating evidence of linkage and linkage disequilibrium from unlinked region. Accepted by Genetic Epidemiology.

141 Miech R, Eaton W, Liang KY (2003). Occupation stratification over the life course: a comparison of occupational trajectories across race and gender during the 1980s and l990s. Accepted by Work and Occupation.

142 Pulver AE, McGrath JA, Liang, KY, Lasseter VK, Nestadt G, Wolyniec PS (2003). No support for the new mutation hypothesis associating advanced paternal age with etiology of schizophrenia. Accepted by Neuropsychiatric Genetics.

143 Liang KY, Hus FC, Beaty TH (2003). Multipoint linkage disequilibrium mapping for complex diseases. Accepted by Genetic Epidemiology.

144 Mackey HM, Zeger SL, Liang KY (2003). A more efficient scalar treatment effect estimated with longitudinal multivariate data. Submitted to Journal of the America Statistical Association.

145 Qin J, Liang KY (2003). Hypothesis testing in a two-component mixture model with two sample data. Submitted to Biostatistics.

146 Hong JP, Samuels J, Bienvenu OJ, Cannistraro P, Grados M, Riddle MA, Liang KY, Cullen B, Nestadt G (2003). Clinical correlates of recurrent major depression in obsessive-compulsive disorder. Submitted to Acta Psychiatrica Scandinavica.

147 McGrath JA, Nestadt G, Liang KY, Lasseter VK, Wolyniec PS, Pulver AE (2003). Five latent factors underlying schizophrenia: analysis and relationship to illness in relatives. Submitted to Schizophrenia Bulletin.

148 Storr CL, Zhou H, Liang KY, Anthony JC (2003). Empirically-derived latent classes of tobacco dependence syndromes observed in a recent-onset tobacco smokers: epidemiological evidence from a national probability sample screen. Submitted to Nicotine and Tobacco Research.

149 Chiu YF, Liang KY (2003). Conditional multipoint linkage analysis using affected sibpairs: an alternative approach. Submitted to Genetic Epidemiology.

150 Aylward EH, Sparks BF, Field KM, Yallapragada V, Shpritz B, Rosenblatt A, Brandt J, Liang KY, Zhou H, Ross CA (2003). The onset and rate of striatal atrophy in pre-symptomatic Huntingtonˇs disease. Submitted to Annals of Neurology.

151 Chen WM, Broman KW, Liang KY (2003). Unification of variance components and Haseman­Elston regression for quantitative trait linkage analysis. Submitted to American Journal of Human Genetics.

152 Liang KY, Chiu YF (2003). Multipoint linkage disequilibrium mapping using case-control designs. Submitted to Biometrics.

153 OˇBrien MS, Liang KY, Anthony JC (2003). Does cannabis use trigger cocaine use? Submitted to Science.

    Books

1Diggle P, Liang KY, Zeger SL (1994). Analysis of Longitudinal Data.Oxford: Oxford University Press.

2Liang KY, Zeger SL (2000). Generalized Linear Models, Estimating Functions and Multivariate Extensions. Lecture Series in Statistics, Institute of Statistical Science, Academia Sinica, Taiwan, R.O.C.

3Diggle P, Heagerty P, Liang KY, Zeger SL (2002). Analysis of Longitudinal Data, 2nd  edition.Oxford:   Oxford University Press.

   Chapters

1Liang KY, Liu X (1991). Estimating equations in generalized linear models with measurement error. Estimating Functions, ed. V.P. Godambe, Oxford: Oxford University Press, pp 47-63.

2Moulton L, Zeger SL, Liang KY (1992). Generalized linear models for longitudinal data, application: Xerophthalmia in Indonesia. Statistical Models for Longitudinal Studies of Health, ed. J.H. Dwyer, M. Feinleib, P. Lippert and H. Hoffmeister. Oxford: Oxford University Press, pp 198-2 14.

3Ware JH, Liang KY (1996). The design and analysis of longitudinal data: a historical perspective. Advances in Biometry, ed. P. Armitage and H.A. David. New York: John Wiley & Sons, pp. 339-362.

4Liang KY, Rathouz PJ (1998). Consistency estimators. In Encyclopedia of Biostatistics, Vol. 1, pp. 908-9 14. New York: John Wiley and Sons.

5Zeger SL, Liang KY (1998). Quasi-likelihood. In Encyclopedia of Biostatistics Vol 5, pp. 3636-3643. New York: John Wiley and Sons.